Table 2 Significant (P < 5e−08) SNPs and genetic loci associated with bacterial and viral infections in the GWAS.

Abdominal infections

rs6717024

C

G

1.133 (1.111–1.156)

1.22e−34

ARHGAP15

rs4333882

G

A

1.081 (1.060–1.103)

2.14e−14

MIR4671, SLC35F3

rs7609897

T

G

0.925 (0.907–0.943)

9.76e−14

COLQ, EAF1, HACL1, METTL6, MIR4270

rs760364725

CA

C

1.062 (1.045–1.079)

5.59e−13

C19orf33, CATSPERG, DPF1, KCNK6, PPP1R14A, SIPA1L3, SPINT2, YIF1B

rs61823192

T

C

0.828 (0.785–0.873)

1.26e−12

LYPLAL1, LYPLAL1-DT

rs1802575

C

G

1.081 (1.056–1.107)

1.56e−11

EFEMP1, MIR217HG

rs11428277

G

GA

1.075 (1.052–1.098)

1.69e−11

COX15, CUTC, ENTPD7, SLC25A28

rs570640158

C

T

1.070 (1.050–1.092)

2.13e−11

HLA-DQA1, HLA-DRB1, HLA-DRB5, HLA-DRB6

rs4782673

T

G

0.945 (0.928–0.961)

1.37e−10

CRISPLD2, USP10

rs7464710

G

C

0.943 (0.926–0.959)

4.13e−10

ENPP2

rs2049865

C

A

0.950 (0.935–0.965)

4.67e−10

TRPS1

rs61817723

A

G

0.945 (0.928–0.961)

4.71e−10

C2CD4D-AS1, NBPF18P, S100A10, S100A11, THEM4, THEM5

rs2276068

C

G

1.050 (1.034–1.067)

1.04e−09

ANO1, FADD, LINC02584, LOC101928443

rs9372625

A

G

0.951 (0.936–0.966)

2.02e−09

rs2280028

A

G

0.932 (0.911–0.955)

3.23e−09

LINC01081, LINC01082, LINC02135

rs71472433

C

A

1.064 (1.041–1.087)

5.24e−09

ANKRD63, BAHD1, BUB1B-PAK6, CCDC9B, DISP2, INAFM2, IVD, KNSTRN, PAK6, PHGR1, PLCB2

rs2973068

G

C

0.947 (0.931–0.964)

8.15e−09

GDNF, GDNF-AS1, WDR70

rs761264338

GGAAG

G

1.050 (1.032–1.069)

1.03e−08

FAM185A, FBXL13, RASA4DP

rs1888693

A

G

0.952 (0.936–0.969)

1.14e−08

CACNB2

rs3732760

C

A

1.048 (1.032–1.065)

1.17e−08

GPR87, IGSF10, MED12L, P2RY12, P2RY13, P2RY14

rs575909118

CT

C

1.053 (1.035–1.072)

1.40e−08

CALCA, CALCB, INSC

rs11030119

A

G

0.951 (0.935–0.968)

1.44e−08

BDNF, BDNF-AS, LINC00678

rs60731259

CA

C

1.096 (1.063–1.131)

1.96e−08

ELN, LIMK1

rs9411377

A

C

0.950 (0.934–0.967)

2.01e−08

MED22, OBP2B, RPL7A, SNORD24, SNORD36A, SNORD36B, SNORD36C, STKLD1, SURF1, SURF2, SURF4, SURF6

rs377411728

T

C

2.641 (1.878–3.714)

2.42e−08

L3MBTL4, L3MBTL4-AS1, MIR4317

Not available

C

CT

1.046 (1.030–1.063)

3.67e−08

PTPN14, SMYD2

Gastroenteritis

rs115809651

A

G

3.525 (2.359–5.269)

8.07e−10

FSTL5

rs138491114

A

G

1.986 (1.557–2.532)

3.14e−08

TBC1D22A

rs772878892

G

A

3.597 (2.274–5.690)

4.77e−08

C16orf78, CBLN1

 a. Bacterial gastroenteritis

rs143977447

A

C

2.375 (1.787–3.156)

2.20e−09

rs547484470

A

C

3.710 (2.396–5.744)

4.13e−09

 b. Viral gastroenteritis

rs116879283

C

T

2.956 (2.033–4.299)

1.49e−08

Heart infections

rs564399474

G

A

4.527 (2.930–6.994)

1.02e−11

MIR1297

rs182592259

A

T

3.589 (2.323–5.546)

8.73e−09

AK7, ATG2B, BDKRB1, BDKRB2, GSKIP

rs139809494

T

C

3.139 (2.117–4.655)

1.30e−08

ALYREF, ANAPC11, ARHGDIA, GCGR, MAFG, MAFG-DT, MCRIP1, NPB, P4HB, PCYT2, PPP1R27, PYCR1, SIRT7

rs2181386

G

A

1.490 (1.294–1.716)

3.51e−08

UNC79

Respiratory tract infections

rs28752520

C

T

0.931 (0.911–0.951)

1.77e−10

HLA-DQA1, HLA-DQB1, HLA-DQB1-AS1, HLA-DRB1, HLA-DRB5, HLA-DRB6

Not available

ATG

A

0.937 (0.919–0.956)

1.94e−10

PBX3

 a. Bacterial pneumonia

rs374402947

T

C

3.391 (2.300–4.998)

6.86e−10

ACSF3, CDH15, LINC00304, LINC02138

rs77438700

G

A

0.839 (0.795–0.887)

7.72e−10

CHRNA3, CHRNA5, CHRNB4, HYKK, PSMA4

rs532298826

A

T

3.056 (2.093–4.461)

6.62e−09

LINC02172, PCDH18

rs763947133

T

C

3.971 (2.466–6.393)

1.33e−08

FBN2

 b. Influenza and viral pneumonia

rs376768393

C

T

3.850 (2.434–6.090)

8.57e−09

DWORF, LINC01487, MME

Sepsis

rs532825748

G

A

2.018 (1.586–2.568)

1.13e−08

C1orf112, METTL18, SCYL3, SELE, SELL

rs147389769

T

C

2.130 (1.638–2.769)

1.60e−08

CAB39, LINC01907

rs564716204

T

C

3.353 (2.200–5.111)

1.90e−08

LRBA

rs539059490

G

T

2.006 (1.567–2.568)

3.65e−08

Sexually transmitted diseases

rs62441491

A

G

3.438 (2.274–5.199)

4.73e−09

INHBA-AS1

Skin infections

rs6595799

C

T

1.092 (1.058–1.127)

2.39e−08

LINC01184, SLC12A2

Specified viral infections

rs568156598

G

A

3.747 (2.397–5.858)

6.68e−09

PPP1R9A

Urinary tract infections (UTI)

rs771331833

A

C

2.989 (2.096–4.262)

1.62e−09

MED30

Not available

A

AT

1.471 (1.285–1.684)

2.81e−08

DHX30, MAP4, MIR1226, SMARCC1

rs189319388

T

C

1.527 (1.313–1.775)

4.63e−08

GRM7

 a. Cystitis

rs192629083

T

C

3.702 (2.396–5.721)

3.50e−09

ETV1

rs77261774

A

G

1.788 (1.461–2.188)

1.49e−08

LINC02429

Urogenital (non-UTI) infections

rs188692128

T

C

3.589 (2.282–5.645)

3.13e−08

Not available

T

TA

3.456 (2.219–5.381)

4.30e−08

RGS7