Figure 2
From: Allele-specific transcription factor binding in a cellular model of orofacial clefting
TFAP2A high confidence peaks (hc-peaks) in human embryonal palatal mesenchyme (HEPM) cells (a) Venn diagram showing the total number of TFAP2A ChIP-seq peaks across two replicates (replicate 1 n = 5820; replicate 2 n = 3989). The overlap of 2845 regions was denoted as „hc-peaks” for the subsequent analyses. Plotted with BioVenn© (2020). (b) Identification of the most abundant binding motif within hc-peaks (present in n = 1535 hc-peaks) with MEME-ChIP. (c) Comparative analysis using Tomtom and JASPAR core 2018 assembly identified the significant alignment of the enriched motif with three distinct TFAP2A binding motifs.
