Table 4 Cox proportional hazard analysis for 60-day mortality according to initial furosemide dose groups.

From: Clinical implication of initial intravenous diuretic dose for acute decompensated heart failure

 

Unadjusted

Adjusted for model 1*

Adjusted for model 2**

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Dose groups

Standard

1 (Reference)

1 (Reference)

1 (Reference)

Below

0.95

0.57–1.58

0.842

1.01

0.48–2.13

0.980

1.18

0.53–2.62

0.692

Above

2.05

1.09–3.88

0.027

3.89

1.70–8.88

0.001

3.11

1.29–7.49

0.011

OPTIME-CHF score (per 1 point)

   

1.01

1.01–1.02

 < 0.001

1.01

1.01–1.02

0.070

D2F time

      

1.00

1.00–1.00

0.977

  1. *Adjusted for the OPTIME-CHF score and log-transformed brain natriuretic peptide.
  2. **Adjusted for Model 1 plus door to furosemide time, dobutamine use within 48 h, dopamine use within 48 h, norepinephrine use within 48 h, phosphodiesterase III inhibitor use within 48 h, vasodilator use within 48 h, total furosemide used within 48 h, and angiotensin-converting enzyme inhibitor/angiotensin II receptor antagonist use within 48 h.
  3. CI confidence interval, D2F door to furosemide, HR hazard ratio.
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