Figure 7 | Scientific Reports

Figure 7

From: PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis

Figure 7

Simplified scheme summarizing transport and metabolism of trehalose and trehalose mycolates in Mtb. Exogenous trehalose is translocated across the mycomembrane via the PPE51 transporter. The LpqY-SugABC transporter allows the uptake of trehalose through the cytoplasmic membrane and recycles free trehalose that is released during synthesis of trehalose dimycolates (TDM) from trehalose monomycolates (TMM) by the mycoloyl transferases of the Antigen 85 complex (Ag85). The Ag85 also catalyzes the synthesis of arabinogalactan-mycolates from TMM, which is not depicted here for the sake of simplicity. Intracellularly, mycolates are conjugated to trehalose to yield TMM involving the enzymes Pks13 and CmrA, whereas the MmpL3 transporter mediates the secretion of TMM. IM inner membrane, AG arabinogalactan.

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