Figure 5
From: Complement C5aR/LPS-induced BDNF and NGF modulation in human dental pulp stem cells
DPSCs produce higher levels of BDNF than BM-MSCs. BDNF in supernatants (A) and cell lysate (B) was measured by enzyme-linked immunosorbent assay after 48 h of treatment. For each experiment/ condition, the BDNF quantity was normalized to cell viability. Stimulation with C5aR-agonist or co-stimulation with LPS significantly increased the BDNF secretion in supernatants of DPSCs compared to BM-MSCs. BDNF secretion in the cell lysate of DPSCs was also significantly higher than BM-MSCs cell lysate. *p < 0.05, **p < 0.01 and ***p < 0.001 versus untreated control of resting cells (n = 3).
