Figure 4 | Scientific Reports

Figure 4

From: Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models

Figure 4

Representative images of histological analysis of DNA damage in RHEs. Paraffin sections are stained for 6-4PP (left column) and CPD damage (right column). Positive cells are stained in dark red. Non-irradiated RHEs (negative control) show no positive cells, while positive epidermal keratinocytes of RHEs irradiated with 40 mJ/cm2 at 254 nm (positive control) were found even in the deeper layers of the epidermis. RHEs irradiated with 3 mJ/cm2 UVB (0.1 MED) showed > 90% CPD damage throughout the whole epidermis. The CPD damage after 40 mJ/cm2 irradiation at 222 nm and 233 nm only occurred at the uppermost layer of the epidermis. Scale bar: 50 µm.

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