Figure 5 | Scientific Reports

Figure 5

From: Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization

Figure 5

Fostamatinib prevents DSA production up to 5 weeks post completion of treatment. Treatment was given from day 1 to day 14 after blood transfusion. Then, the antibody levels were monitored until day 49. T lymphocyte crossmatch analysis was performed to detect DSA levels in sensitized fostamatinib and vehicle dosed LEW rats. (A) IgM and (B) IgG production was inhibited up to 5 weeks post-termination of the fostamatinib treatment regimen (n = 6 rats/group) (*P ≤ 0.05, **P ≤ 0.01). Blue filled circle—vehicle, red filled triangle—fostamatinib.

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