Table 4 Summary of the treatments in the 22 eligible studies.
Author Yr, Country | Surgery | HIPEC group | Control group |
|---|---|---|---|
Liu 2020, China | Radical gastrectomy | Surgery + HIPEC + systemic chemotherapy HIPEC: Oxaliplatin (100 mg/m2) and 0.9% sodium chloride solution (3000 mL) at 1.4 days; fluorouracil (0.75 g) and 0.9% sodium chloride solution (3000 mL) at 2.3 days; Dexamethasone (10 mg) and 2% lidocaine (10 mL) 1–4 days Time: postoperative 1 to 2 days (once a day, lasting 90 min each time), last for 4 days Temperature: 42–44 °C | Surgery + systemic chemotherapy (Paclitaxel 135 mg/m2(1 day), cisplatin 20 mg/m2 and tegafur 1.0 g (1–5 days), 4 weeks × 6 cycles) Time: 2 weeks postoperative |
Cui 2014, China | Radical resection of the gastric cancer | Surgery + HIPEC + systemic chemotherapy HIPEC: Cisplatin (60 mg/m2) and 0.9% sodium chloride solution (3000 mL) at 1.4 days; fluorouracil (0.75 g) and 0.9% sodium chloride solution (3000 mL) at 2.3 days; Dexamethasone (10 mg) and 2% lidocaine (10 mL) 1–4 days Time: postoperative 1 to 2 days (once a day, lasting 90 min each time), last for 4 days Temperature: 41–43 °C | Surgery + ECF (50 mg/m2 epirubicin and 60 mg/m2 cisplatin administered via an intravenous drip on day 1 and 600 mg/m2 fluorouracil administered via an intravenous drip between day 1 and 3) |
Fujimura 1994, Japan | Curative resection | Surgery + HIPEC HIPEC: MMC (30 mg) and cisplatinum (300 mg) in 10 L saline solution Time: 60 min Temperature: 41–42 °C | Surgery |
Fan 2021, China | Radical gastrectomy | Surgery + HIPEC + chemotherapy with SOX regime HIPEC: Cisplatin (50 mg/L) and 0.9% sodium chloride solution Time: 30 min Temperature: 42.5–43 °C | Surgery + chemotherapy with SOX regime (S-1, 40–60 mg (40 mg when BSA < 1.25 m2, 60 mg when BSA > 1.5 m2), twice per day, Day 1–14; Oxaliplatin (130 mg/m2) was given intravenously at the first day of each cycle) |
Hamazoe 1994, Japan | Radical gastrectomy | Surgery + HIPEC HIPEC: MMC (10 μg/mL) in 0.9% saline solution Time: 50–60 min Temperature: 44–45 °C | Surgery |
Xie 2020, China | Laparoscopic-assisted radical gastrectomy | Surgery + HIPEC + systemic chemotherapy (SELOX or SOX) HIPEC: Cisplatin (50 mg/L) and 0.9% sodium chloride solution Time: 60 min Temperature: 42–43 °C | Surgery + XELOX or SOX chemotherapy at 4–6 weeks after surgery and received a total of 6–8 cycles every 3 weeks. (Regimen: Oxaliplatin 130 mg/m2 ivgtt d1 + xeloda 1500 mg/m2 BID PO d1–15)) |
Reutovich 2019, Belarus | Total or partial (distal subtotal resection) gastrectomy with free margins (R0 resection) and D2 lymph node dissection | Surgery + HIPEC HIPEC: Ringer's solution (5–6 L), cisplatin (50 mg/m2) and doxorubicin (50 mg/m2) Temperature: 42 °C | Surgery |
Koga 1988, Japan | Curative surgery | Surgery + HIPEC HIPEC: MMC (8–10 mg/L) in 2000 mL saline solution Time: 50–60 min Temperature: 44–45 °C | Surgery |
Rosa 2021, Italy | Gastrectomy | Surgery + HIPEC HIPEC: Cisplatin (75 mg/m2), MMC (15 mg/m2), and 0.9% sodium chloride solution (2 L/m2) Time: 90 min Temperature: 41–42 °C | Surgery |
Zhu 2020, China | Gastrectomy | Surgery + HIPEC + chemotherapy HIPEC: Cisplatin (75 mg/m2) and 2000 mL 0.9% sodium chloride solution Time: 60 min Temperature: 41.5–42.5 °C | Surgery + chemotherapy intravenous 5-fluorouracil (500 mg/m2) and LV (200 mg/m2) on days 1 to 5, and intravenous cisplatin (25 mg/m2) on days 1 to 3 |
Diniz 2020, Brazil | Curative resection | Perioperative chemotherapy + surgery + HIPEC HIPEC: MMC (38 mg/m2) in saline solution Time: 90 min Temperature: 41–42 °C | Perioperative chemotherapy + surgery (a) Platinum‐based doublets (Carboplatin + Paclitaxel, Carboplatin + 5‐FU, CDDP + 5‐FU, FOLFOX, XELOX, FLOX) (b) Epirubicin‐based triplets (ECF, ECX, EOX) (c) Taxane‐based triplets (DCF, DCX) |
Zhong 2020, China | Laparoscopic-assisted radical gastrectomy | Surgery + HIPEC HIPEC: Lobaplatin (50 mg/m2) and 3000 mL 5% intravenous glucose solution Time: 60 min Temperature: 43 °C | Surgery + chemotherapy 400 mg UFT [a combination of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil in a molar ratio of 1:4] per day orally on consecutive days for the first 2 to 3 postoperative weeks |
Yonemura 1995, Japan | Gastrectomy | Surgery + HIPEC HIPEC: Cisplatin (300 mg), MMC (30 mg), and 0.9% sodium chloride solution (8 L) Time: 60 min Temperature: 41.5–43.5 °C | Surgery |
Fujimoto 1999, Japan | Gastrectomy | Surgery + HIPEC HIPEC: MMC (10 mg/mL), and 0.9% sodium chloride solution (3–4 L) Time: 120 min Temperature: 44.5–45 °C | Surgery |
Kim 2001, Korea | Subtotal or total gastrectomy | Surgery + HIPEC HIPEC: MMC (40 mg), and dialysis solution (4000 cc) Time: 120 min Temperature: 44.5–45.7 °C | Surgery + chemotherapy 5-fluorouracil (FU) or 5-FU in combination with MMC at least six cycles |
Hirose 1999, Japan | Gastrectomy | Surgery + HIPEC HIPEC: cisplatin (100 mg), MMC (20 mg) and etoposide (100 mg) Temperature: 41–44.5 °C | Surgery + chemotherapy Two to 3 weeks after the operation, MMC (6 mg/m2) and 5-fluorouracil (5FU, 375 mg/m2) were intravenously administered once a week, and this MMC-5FU therapy was repeated for 3 consecutive weeks before the patient’s discharge from the hospital |
Ikeguchi 1995, Japan | Curative resection | Surgery + HIPEC HIPEC: MMC (80–100 mg/m2), 8–10 L Time: 50–60 min Temperature: 44–45 °C | Surgery + chemotherapy intravenous injection of MMC 20 mg on day 0 and MMC 10 mg on days 7 and 14, and took 1-(2tetrahydrofuryl)-5-fluorouracil/uracil (1:4) 600 mg/day orally from day 14 for at least 6 months |
Takahashi 1995, Japan | Gastrectomy | Surgery + HIPEC HIPEC: MMC (50 mg), Activated carbon (375 mg), Saline (100 mL) | Surgery |
Beeharry 2019, China | Standardized radical gastrectomy with D2 lymphadenectomy | Surgery + HIPEC HIPEC: cisplatin (50 mg/L) Time: 60 min Temperature: 41–43 °C | Surgery + XELOX 6 regimens of standard dosage of the XELOX regimen starting within 1 month after surgery (Regimen: Oxaliplacin 130 mg/m2 ivgtt d1 + Xeloda 1500 mg/m2bid po d1–15, Q3W) |
Kunisaki 2002, Japan | Gastrectomy | Surgery + HIPEC HIPEC: Cisplatin (150 mg), MMC (15 mg), and etoposide (150 mg) in 5 to 6 L physiologic saline Time: 40 min Temperature: 42–43 °C | Surgery |
Kang 2013, Taiwan, ROC | Gastrectomy | Surgery + HIPEC HIPEC: cisplatin (30 mg/L), MMC (10 mg/L), and etoposide (20 mg/L) in 3–4 L of lactated Ringer solution Time: 60 min Temperature: 41–43 °C | Surgery |
Yarema 2014, Ukraine | Gastrectomy | Surgery + HIPEC HIPEC: MMC (12.5 mg/m2), cisplatin (75 mg/m2) Time: 90 min Temperature: 41–43.6 °C | Surgery |
