Table 2 Characteristics of instrumental variables used in the Mendelian randomization analyses in East Asian ancestry.
From: Association between type 2 diabetes and amyotrophic lateral sclerosis
Exposure | Published genome-wide association study of the T2D etc | Present Mendelian randomization analysis | ||||
|---|---|---|---|---|---|---|
References | Maximum sample size | No. of independent genome-wide significant SNPs | No. of SNPs included in the analysis | Proxies used (r2 > 0.9) | Excluded (no proxy at r2 > 0.9) | |
T2D | Li et al.16 | 32,974 | 10 | 8 | 2 | |
Glucose | Hwang et al.17 | 24,740 | 14 | 14 | ||
Glycated hemoglobin | Chen et al.18 | ~30,000 | 12 | 11 | 1 | |
BMI | Wen et al.19 | 27,715 | 13 | 12 | 1 | |
WCadjBMI | Wen et al.20 | 16,378 | 4 | 4 | ||
