Figure 1

The mutated gene signature of colorectal adenomas and in situ carcinomas. (A) The APC promoter methylation distribution with POLE genetic variations, (B) The mutation distribution of APC gene between low-, high-grade adenomas and in situ carcinomas, (C) The mutation distribution of KRAS gene between low-, high-grade adenomas and in situ carcinomas, (D) The mutation distribution of TP53 gene between low-, high-grade adenomas and in situ carcinomas, (E) The mutation distribution of POLE gene between low-, high-grade adenomas and in situ carcinomas, (F) The Venn diagram of mutations of APC, TP53, and KRAS genes in in situ carcinomas, (G) The Venn diagram of mutations of APC, TP53, KRAS, and POLE genes in adenomas.