Table 1 Baseline characteristics P2X4-Knockout Study.
From: P2X4 deficiency reduces atherosclerosis and plaque inflammation in mice
LDL-R−/− | P2X4−/− LDL-R−/− | p value | ||
|---|---|---|---|---|
Total leukocytes, tsd/µL | Before diet | 5.94 ± 0.35 | 3.82 ± 0.24 | *** |
After diet | 7.19 ± 0.83 | 9.5 ± 0.68 | * | |
Neutrophils/leukocytes, % | Before diet | 10 ± 1.5 | 11 ± 1 | ns |
After diet | 18 ± 1.3 | 18 ± 1.9 | ns | |
B-cells/leukocytes, % | Before diet | 46 ± 1.9 | 51 ± 2.1 | ns |
After diet | 43 ± 1.1 | 42 ± 3.6 | ns | |
T-cells/leukocytes, % | Before diet | 23 ± 0.69 | 17 ± 1.4 | ** |
After diet | 15 ± 1 | 9.4 ± 0.97 | *** | |
CD4+ cells/T-cells, % | Before diet | 61 ± 1 | 48 ± 1.8 | **** |
After diet | 51 ± 2.5 | 38 ± 3 | ** | |
CD8+ cells/T-cells, % | Before diet | 39 ± 1 | 52 ± 1.8 | **** |
After diet | 49 ± 2.2 | 62 ± 3 | ** | |
Monocytes/leukocytes, % | Before diet | 4.93 ± 0.57 | 5.795 ± 0.53 | ns |
After diet | 11 ± 0.98 | 13 ± 0.95 | ns | |
Ly6C high monocytes/monocytes, % | Before diet | 46 ± 3.1 | 39 ± 1.1 | * |
After diet | 65 ± 2.8 | 54 ± 2.1 | ** | |
Ly6C low monocytes/monocytes, % | Before diet | 54 ± 3.1 | 61 ± 1.1 | * |
After diet | 35 ± 2.8 | 46 ± 2.1 | ** | |
Weight (g) | Before diet | 21.06 ± 0.54 | 21.02 ± 0.28 | ns |
After diet | 33.79 ± 1.1 | 35.54 ± 0.94 | ns | |
Total cholesterol (mg/dL) | After diet | 2200 ± 190 | 2271 ± 142 | ns |
Total triglycerides (mg/dL) | After diet | 722 ± 100 | 607 ± 37 | ns |
