Table 1 Quantitative results for IVO (top) and ProstateX (bottom) test data evaluated with different Gleason Grade Group (GGG) significance criteria (e.g. lesions with GGG\(\ge\)1, 2, or 3 are considered positive), at lesion- and patient-level (\(N_{positives}/N_{total}\)), and at two thresholds (t): maximum sensitivity and balanced. For IVO data, results are compared with radiologist-assigned pre-biopsy PI-RADS scores for all IVO patients with no missing sequences and with PI-RADS information available (N=106 patients, 111 lesions). AUC: Area under the ROC curve.
(Dataset) & Significance criterion | Level | AUC | Max. sensitivity | Balanced | PI-RADS\(\ge\)4 | PI-RADS=5 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
t | Sens. | Spec. | t | Sens. | Spec. | Sens. | Spec. | Sens. | Spec. | |||
IVO GGG\(\ge\)1 | Lesion (\(13/33\)) | 0.892 | 0.027 | 1.000 | 0.350 | 0.105 | 0.923 | 0.700 | 0.741 | 0.604 | 0.328 | 0.962 |
Patient (15/30) | 0.920 | 0.253 | 1.000 | 0.667 | 0.301 | 0.867 | 0.800 | 0.710 | 0.649 | 0.290 | 0.973 | |
IVO GGG\(\ge\)2 | Lesion (8/33) | 0.945 | 0.173 | 1.000 | 0.800 | 0.301 | 0.875 | 0.920 | 0.882 | 0.558 | 0.441 | 0.922 |
Patient (9/30) | 0.910 | 0.219 | 1.000 | 0.762 | 0.262 | 0.889 | 0.810 | 0.850 | 0.576 | 0.400 | 0.924 | |
IVO GGG\(\ge\)3 | Lesion (3/33) | 0.856 | 0.301 | 1.000 | 0.800 | 0.315 | 0.667 | 0.867 | 0.727 | 0.440 | 0.455 | 0.840 |
Patient (3/30) | 0.840 | 0.301 | 1.000 | 0.778 | 0.315 | 0.667 | 0.852 | 0.727 | 0.432 | 0.455 | 0.832 | |
ProstateX GGG\(\ge\)1 | Lesion (17/69) | 0.898 | 0.028 | 0.941 | 0.788 | 0.053 | 0.824 | 0.865 | – | – | – | – |
Patient (16/45) | 0.866 | 0.108 | 1.000 | 0.138 | 0.104 | 0.938 | 0.655 | – | – | – | – | |
ProstateX GGG\(\ge\)2 | Lesion (13/69) | 0.959 | 0.028 | 1.000 | 0.786 | 0.108 | 0.923 | 0.911 | – | – | – | – |
Patient (13/45) | 0.865 | 0.028 | 1.000 | 0.375 | 0.108 | 0.923 | 0.688 | – | – | – | – | |
ProstateX GGG\(\ge\)3 | Lesion (7/69) | 0.751 | 0.195 | 0.714 | 0.887 | 0.195 | 0.714 | 0.887 | – | – | – | – |
Patient (7/45) | 0.767 | 0.016 | 1.000 | 0.395 | 0.026 | 0.857 | 0.500 | – | – | – | – | |
