Table 1 Characteristics of participants included in the analyses (n = 2872).
From: Retinal layer assessments as potential biomarkers for brain atrophy in the Rhineland Study
Mean ± SD or n(%) | |
|---|---|
Age (years) | 53.8 ± 13.2 |
Women | 1649 (57.4%) |
Spherical equivalent (dpt) | − 0.65 ± 2.5 |
Body-Mass-Index (kg/m2) | 25.6 ± 4.2 |
Smoking status | |
Never | 1390 (48.4%) |
Former | 1103 (38.4%) |
Current | 379 (13.2%) |
Hypertension | 980 (34%) |
Diabetes mellitus | 116 (4%) |
Brain volumetric parameters (in ml) | |
Total brain | 1111.0 ± 116.1 |
Total grey matter | 461.2 ± 47.5 |
Total white matter | 458.2 ± 57.8 |
Occipital grey matter | 48.3 ± 6.2 |
Occipital white matter | 42.4 ± 6.2 |
Hippocampi | 7.92 ± 0.9 |
Fractional anisotropy (FA) of total white mattera | 0.629 ± 0.02 |
FA of WM of the optic radiationa | 0.628 ± 0.02 |
Macular volumetric parameters (in mm3) | |
Retinal nerve fiber layer (mRNFL) | 0.95 ± 0.12 |
Ganglion cell layer (mGCL) | 1.08 ± 0.10 |
Inner plexiform layer (mIPL) | 0.89 ± 0.07 |
Inner nuclear layer (mINL) | 0.95 ± 0.06 |
Outer plexiform layer (mOPL) | 0.82 ± 0.07 |
Outer nuclear layer (mONL) | 1.73 ± 0.19 |
Retinal pigment epithelium (mRPE) | 0.39 ± 0.04 |
Total retina | 8.66 ± 0.39 |
Optic disc thickness parameters (in microns) | |
Peripapillary retinal nerve fiber layer (pRNFL) | 100.0 ± 10.8 |
Bruch’s membrane opening–minimum rim width (BMO–MRW) | 341.3 ± 61.3 |
