Table 2 Associations of retinal layers with brain volumetric parameters (n = 2872).
From: Retinal layer assessments as potential biomarkers for brain atrophy in the Rhineland Study
Total brain volume | Total grey matter volume | Total white matter volume | |||||||
|---|---|---|---|---|---|---|---|---|---|
Difference (%) per mm3/µm [95% CI] | Difference (%) per SD [95% CI] | p | Difference (%) per mm3/µm [95% CI] | Difference (%) per SD [95% CI] | p | Difference (%) per mm3/µm [95% CI] | Difference (%) per SD [95% CI] | p | |
mRNFL | 1.58 [0.43; 2.74] | 0.19 [0.05; 0.33] | 0.007 | 0.34 [-1.04; 1.72] | 0.04 [-0.13; 0.21] | 0.63 | 2.89 [1.01; 4.76] | 0.35 [0.12; 0.58] | 0.002 |
mGCL | 7.08 [5.61; 8.55] | 0.70 [0.56; 0.85] | < 0.001 | 5.45 [3.67; 7.22] | 0.54 [0.37; 0.72] | < 0.001 | 8.58 [6.17; 10.99] | 0.86 [0.62; 1.10] | < 0.001 |
mIPL | 8.61 [6.68; 10.55] | 0.64 [0.49; 0.78] | < 0.001 | 6.94 [4.60; 9.27] | 0.51 [0.34; 0.69] | < 0.001 | 9.89 [6.72; 13.07] | 0.73 [0.50; 0.97] | < 0.001 |
mINL | 3.17 [0.96; 5.39] | 0.21 [0.06; 0.35] | 0.005 | 0.85 [-1.80; 3.50] | 0.05 [-0.12; 0.23] | 0.53 | 4.46 [0.86; 8.06] | 0.29 [0.05; 0.52] | 0.02 |
mOPL | 2.76 [0.87; 4.66] | 0.20 [0.06; 0.33] | 0.004 | 2.11 [-0.15; 4.38] | 0.15 [-0.01; 0.31] | 0.07 | 3.37 [0.28; 6.45] | 0.24 [0.02; 0.46] | 0.03 |
mONL | 0.41 [-0.33; 1.15] | 0.07 [-0.06; 0.22] | 0.28 | 0.73 [-0.16; 1.62] | 0.14 [-0.03; 0.31] | 0.10 | -0.24 [-1.45; 0.96] | -0.04 [-0.27; 0.18] | 0.69 |
mRPE | 5.89 [2.01; 9.77] | 0.21 [0.07; 0.34] | 0.003 | 6.59 [1.95; 11.22] | 0.23 [0.07; 0.40] | 0.005 | 3.99 [-2.33; 10.31] | 0.14 [-0.08; 0.36] | 0.22 |
pRNFL | 0.04 [0.03; 0.06] | 0.49 [0.35; 0.64] | < 0.001 | 0.02 [0.01; 0.04] | 0.25 [0.08; 0.42] | 0.004 | 0.06 [0.04; 0.08] | 0.61 [0.38; 0.84] | < 0.001 |
BMO–MRW | 0.00 [0.00; 0.01] | 0.25 [0.10; 0.39] | < 0.001 | 0.00 [0.00; 0.00] | 0.00 [-0.18; 0.16] | 0.92 | 0.01 [0.00; 0.01] | 0.42 [0.19; 0.65] | < 0.001 |
