Figure 2 | Scientific Reports

Figure 2

From: Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy

Figure 2

Differentially expressed genes mainly correlated with T cell activations. (A) Volcano plot of the 360 clinical remission-related DEGs. Fold Change > 2 & p-value < 0.01 were set as screening criteria. DEGs differentially expressed genes. Responders represent CR; Non-responders represent NR; (B) Unsupervised clustering heatmap of the differential expression genes between responders and non-responders; (C) Principal component analysis in CR and NR based on differentially expressed genes; (D) Gene oncology analysis for upregulated genes. BP biological process; CC cellular component; MF molecular function. Circle size means gene number involved in each term. Circle color means p-adjust value.

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