Figure 1 | Scientific Reports

Figure 1

From: Histopathology and surgical outcome of symptomatic treatment-related changes after gamma knife radiosurgery in patients with brain metastases

Figure 1

Flow chart of patient enrollment and classification. Eighty-six patients were included and classified into four groups according to preoperative MRI and surgical pathology. For surgical pathology, pure radiation necrosis alone was sorted into “radiation necrosis”. Mixed pathology, containing both metastatic tumor and necrotic cells, was classified as “metastatic cells.” No patient was assigned to the PD-RN group; therefore, the three groups TRC-RN, TRC-PD, and PD–PD were finally incorporated in this study. MRI magnetic resonance imaging, PD progressive disease, RN radiation necrosis, TRC treatment-related change.

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