Figure 10
From: Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice
Role of iNOS/NO pathway in sepsis-induced attenuation of Notch signaling. Bar diagrams showing the effect of in vivo treatment with 1400 W, a selective inhibitor of inducible nitric oxide synthase (iNOS), on sepsis-induced attenuation of mRNA expression of Notch3 receptor (A), Jag1 ligand (B) and MLCK (C) genes in mouse aorta. SO sham-operated, CLP sepsis. Data are presented as mean ± SEM. Vertical bars represent SEM; n = 4–7. Data were analyzed by one-way ANOVA followed by Tukey’s post-hoc test. *p < 0.05 vs. CLP; #p < 0.05 vs. 1400 W + CLP.
