Figure 6
From: Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice
Effect of DAPT treatment on comparative aortic Notch signaling and its effector genes. Bar diagrams showing the effect of in vivo treatment with DAPT, a selective inhibitor of γ-secretase, on mRNA expression of Notch3 receptor (A), Jag1 ligand (B), Hey1 (C) and MLCK (D) genes in the aorta of SO and CLP mice. SO sham-operated, CLP sepsis. Data are presented as mean ± SEM. Vertical bars represent SEM; n = 7–8. Data were analyzed by one-way ANOVA followed by Tukey’s post-hoc test. *p < 0.05 vs. SO, #p < 0.05 vs. DAPT + SO.
