Figure 8
From: Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice
Effect of DAPT pre-treatment on hyporeactivity of the aortic ring to nor-adrenaline (NA) in septic mice. Representative tracings show the concentration-dependent contractile response to NA (0.1 nM–1 µM) in the aorta from sham-operated (SO; A), sepsis (CLP; B), DAPT pre-treated SO (DAPT + SO; C) and DAPT pre-treated sepsis (DAPT + CLP; D) groups. Comparative line diagrams (E–G) showing the mean concentration–response curves of NA from different groups. Data are presented as mean ± SEM; n = 6. Vertical bars represent SEM. Data were analyzed by two-way ANOVA followed by Bonferroni post-hoc tests. *p < 0.05 in comparison to SO.
