Table 3 Association of serotype with meningitis or nonmeningitis cases among adults in Japan during 2014⎼2018.
Variables | No. (%) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
Total cases | Meningitis | Nonmeningitis | OR (95% CI) | p-value | aOR (95% CI) | p-value | |
(n = 1480) | (n = 222) | (n = 1258) | |||||
Age years | 71 (62–82) | 66 (57–75) | 72 (63–83) | ||||
≧65 years | 1013 (68.4) | 124 (55.9) | 889 (70.7) | 0.53 (0.39–0.70) | < 0.001 | 0.59 (0.44–0.81) | < 0.001 |
Asplenia/ hyposplenia, or splenectomy | 59 (4.1%) | 21 (9.5%) | 38 (3.0%) | 3.35 (1.93–5.83) | < 0.001 | 2.29 (1.27–4.14) | 0.006 |
Serotype | |||||||
3 | 187 (12.6) | 18 (8.1) | 169 (13.4) | 0.57 (0.34–0.95) | 0.03 | 0.77 (0.46–1.31) | 0.334 |
12F | 154 (10.4) | 18 (8.1) | 136 (10.8) | 0.73 (0.44–1.22) | 0.226 | ||
19A | 138 (9.3) | 4 (1.8) | 134 (10.7) | 0.15 (0.06–0.42) | < 0.001 | 0.20 (0.07–0.56) | 0.002 |
10A | 112 (7.6) | 39 (17.6) | 73 (5.8) | 3.46 (2.28–5.26) | < 0.001 | 3.26 (2.10–5.06) | < 0.001 |
23A | 97 (6.6) | 37 (16.7) | 60 (4.8) | 3.99 (2.58–6.19) | < 0.001 | 3.91 (2.47–6.19) | < 0.001 |
22F | 89 (6.0) | 9 (4.1) | 80 (6.4) | 0.62 (0.31–1.26) | 0.187 | ||
35B | 81 (5.5) | 14 (6.3) | 67 (5.3) | 1.20 (0.66–2.17) | 0.554 | ||
15A | 75 (5.1) | 14 (6.3) | 61 (4.8) | 1.32 (0.73–2.41) | 0.363 | ||
6C | 74 (5.0) | 9 (4.1) | 65 (5.2) | 0.78 (0.38–1.58) | 0.484 | ||
11A/E | 56 (3.8) | 12 (5.4) | 44 (3.5) | 1.58 (0.82–3.04) | 0.173 | ||
Other serotypes | 417 (28.2) | 48 (21.6) | 369 (29.3) | ||||
