Table 4 Susceptibility of pneumococcal isolates from meningitis and nonmeningitis cases against four antimicrobial agents.

From: Pneumococcal meningitis in adults in 2014–2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan

Antimicrobial agents

The pneumococcal strains isolated from; No of strain (%)

Meningitis (n = 222)

Nonmeningitis (n = 1254)

Susceptible

Intermediate

Resistant

MIC50 (μg/mL)

MIC90 (μg/mL)

Susceptible

Intermediate

Resistant

MIC50 (μg/mL)

MIC90 (μg/mL)

Penicillin G

144 (64.9)

–*

78 (35.1)

0.03

1

1240 (98.9)

9 (0.7)

5 (0.4)

0.03

1

Ceftriaxone

209 (94.1)

10 (4.5)

3 (1.4)

0.25

0.5

1230 (98.1)

12 (1.0)

12 (1.0)

0.25

0.5

Meropenem

208 (93.7)

14 (6.3)

0 (0)

0.015

0.25

1157 (92.3)

87 (6.9)

10 (0.8)

0.015

0.25

Vancomycin

222 (100)

–*

–*

0.25

0.5

1254 (100)

–*

–*

0.25

0.5

  1. * Breakpoint undefined.