Table 4 The dose–response associations of prenatal canned fish with cord blood total IgE elevation modified by IL13 genetic polymorphisms.

From: Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Canned fisha

IL13 rs1800925

IL13 rs20541

CC

(n = 797)

aOR (95% CI)

CT or TT

(n = 310)

aOR (95% CI)

GG

(n = 496)

aOR (95% CI)

GA or AA

(n = 611)

aOR (95% CI)

None

1

1

1

1

 < monthly

0.98 (0.67–1.44)

1.62 (0.87–2.99)

0.75 (0.45–1.24)

1.54 (1.01–2.35)*

 ≥ monthly

0.84 (0.47–1.49)

2.81 (1.24–6.36)*†

1.02 (0.50–2.06)

1.49 (0.81–2.76)

P for trend

0.61

0.01

0.66

0.07

P for interaction

 

0.02

 

0.15

  1. aOR, adjusted odds ratio; 95% CI, 95% confidence interval.
  2. *P < .05, †P < .05 after FDR correction.
  3. aAdjusted for neonatal sex, gestational age, birth body weight, maternal age, parental education, family history of atopic diseases, environmental tobacco smoke, and perception of mildewy odor.
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