Table 5 Dose–response associations of prenatal food protective index with cord blood total IgE elevation modified by genetic polymorphisms.
PFPI#,a | Total | IL13 rs1800925 | IL13 rs20541 | IL13 rs848 | |||
|---|---|---|---|---|---|---|---|
(n = 1107) aOR (95% CI) | CC (n = 797) aOR (95% CI) | CT or TT (n = 310) aOR (95% CI) | GG (n = 496) aOR (95% CI) | GA or AA (n = 611) aOR (95% CI) | CC (n = 501) aOR (95% CI) | CA or AA (n = 605) aOR (95% CI) | |
None | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
1 | 0.58 (0.32–1.05) | 0.71 (0.33–1.54) | 0.40 (0.15–1.09) | 0.42 (0.15–1.16) | 0.77 (0.36–1.62) | 0.47 (0.17–1.29) | 0.71 (0.34–1.52) |
2 | 0.43 (0.24–0.78)**‡ | 0.55 (0.26–1.19) | 0.31 (0.11–0.82)*† | 0.46 (0.17–1.22) | 0.44 (0.21–0.92)*† | 0.47 (0.18–1.26) | 0.44 (0.21–0.92)*† |
3 | 0.37 (0.19–0.73)**‡ | 0.53 (0.23–1.24) | 0.21 (0.07–0.66)**† | 0.67 (0.23–1.94) | 0.23 (0.09–0.57)**‡ | 0.63 (0.22–1.82) | 0.27 (0.11–0.65)**† |
P for trend | 0.002 | 0.09 | 0.009 | 0.73 | < 0.0001 | 0.91 | 0.0002 |
P for interaction | 0.15 | 0.004 | 0.03 | ||||
PFPI#,a | STAT6 rs324011 | IL4 rs2243250 | |||||
|---|---|---|---|---|---|---|---|
CC (n = 628) aOR (95% CI) | CT or TT (n = 479) aOR (95% CI) | TT (n = 724) aOR (95% CI) | TC or CC (n = 381) aOR (95% CI) | ||||
None | 1 | 1 | 1 | 1 | |||
1 | 0.52 (0.24–1.15) | 0.66 (0.26–1.69) | 0.56 (0.26–1.20) | 0.53 (0.20–1.40) | |||
2 | 0.39 (0.18–0.85)*† | 0.48 (0.19–1.21) | 0.42 (0.20–0.88)* | 0.38 (0.14–1.01) | |||
3 | 0.32 (0.13–0.75)**† | 0.43 (0.15–1.27) | 0.41 (0.18–0.95)* | 0.28 (0.09–0.87)* | |||
P for trend | 0.007 | 0.07 | 0.03 | 0.02 | |||
P for interaction | 0.77 | 0.62 | |||||
