Table 1 Biodistribution of [131I]SGMIB-2Rs15d in NOD SCID mice bearing BT474 xenografts.
Percent injected dose per gram of tissuea | |||||
|---|---|---|---|---|---|
Tissues | 1Â h | 4Â h | 8Â h | 16Â h | 24Â h |
Liver | 5.3 ± 0.7 | 3.5 ± 0.8 | 2.2 ± 0.1 | 0.1 ± 0.0 | 0.0 ± 0.0 |
Spleen | 1.2 ± 0.3 | 1.5 ± 0.9 | 0.6 ± 0.2 | 0.1 ± 0.0 | 0.0 ± 0.0 |
Lungs | 2.8 ± 0.8 | 2.5 ± 1.0 | 1.2 ± 0.4 | 1.3 ± 0.7 | 0.1 ± 0.1 |
Heart | 0.7 ± 0.3 | 0.3 ± 0.2 | 0.2 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Kidneys | 74.1 ± 14.2 | 15.4 ± 7.1 | 7.1 ± 4.9 | 0.6 ± 0.3 | 0.5 ± 0.2 |
Stomach | 1.1 ± 0.4 | 1.0 ± 0.8 | 0.9 ± 0.5 | 0.3 ± 0.3 | 0.1 ± 0.0 |
Thyroid | 0.4 ± 0.3 | 0.4 ± 0.2 | 0.3 ± 0.2 | 0.1 ± 0.0 | 0.1 ± 0.1 |
Sm. Int | 1.1 ± 0.3 | 1.4 ± 0.7 | 2.4 ± 4.0 | 0.3 ± 0.3 | 0.1 ± 0.0 |
Lg. Int | 0.3 ± 0.1 | 2.2 ± 1.8 | 5.0 ± 3.6 | 0.9 ± 0.5 | 0.2 ± 0.1 |
Muscle | 0.4 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Blood | 1.5 ± 0.5 | 0.8 ± 0.2 | 0.5 ± 0.3 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Bone | 0.5 ± 0.2 | 0.2 ± 0.1 | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Brain | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Tumor | 17.1 ± 6.0 | 17.7 ± 4.7 | 11.0 ± 2.3 | 8.5 ± 2.2 | 5.7 ± 1.3 |
