Table 2 Fasting blood glucose levels of alloxan-induced diabetic rats before and after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Treatment groups

Before alloxan administration

After 48 h of alloxan administration

After 7 days of P. americana extract administration

After 14 days of P. americana extract administration

Normal control

69.91 ± 1.73

69.91 ± 1.73

69.91 ± 1.73

79.92 ± 1.94

Diabetic control

67.68 ± 2.88

365.38 ± 64.45#

395.82 ± 16.92#

444.96 ± 38.57#

Diabetic + metformin

53.10 ± 0.95

398.70 ± 72.23#

325.35 ± 61.22#

88.38 ± 3.12*

Diabetic + AEPAS (26.7 mg/kg)

57.24 ± 4.17

450.90 ± 36.59#

217.22 ± 2.14**

118.22 ± 14.34*

Diabetic + AEPAS (53.3 mg/kg)

40.32 ± 5.10

376.92 ± 15.30#

216.36 ± 27.92**#

88.56 ± 6.11*

Diabetic + AEPAS (106.6 mg/kg)

62.37 ± 4.27

290.78 ± 59.89#

99.99 ± 7.79*

85.68 ± 4.36*

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC; **P < 0.01 is considered as very significant.
  2. AEPAS: Aqueous extract of P. americana seeds.
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