Table 3 Body weight of alloxan-induced diabetic rats before and after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Treatment groups

Initial weight (g)

Final weight (g)

% weight change

Normal control

243.57 ± 11.12

255.46 ± 7.08

11.89↑

Diabetic control

242.06 ± 14.79*

188.05 ± 24.28#

− 54.01↓

Diabetic + metformin

245.33 ± 9.42*

210.27 ± 11.84*

− 35.06↓

Diabetic + AEPAS (26.7 mg/kg)

252.72 ± 2.69*

240.37 ± 2.82*

− 12.35↓

Diabetic + AEPAS (53.3 mg/kg)

247.55 ± 2.33*

254.50 ± 0.83*

6.95↑

Diabetic + AEPAS (106.6 mg/kg)

254.75 ± 1.98*

274.01 ± 6.74*

19.26↑

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC.
  2. AEPAS: Aqueous extract of P. americana seeds; Weight loss (↓); Weight gain (↑).
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