Table 4 Serum insulin levels and HOMA-IR and HOMA-β scores of alloxan-induced diabetic rats after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Groups

Parameters

Insulin (U/l)

HOMA-IR

HOMA-β

Normal control

10.55 ± 0.03

2.03 ± 0.07

268.81 ± 45.62

Diabetic control

5.74 ± 0.40#

7.07 ± 0.38#

4.75 ± 0.48#

Diabetic + metformin

7.49 ± 0.05*

1.55 ± 0.04*

133.05 ± 18.44*

Diabetic + AEPAS (26.7 mg/kg)

9.30 ± 0.06*

2.27 ± 0.29*

150.72 ± 81.47*

Diabetic + AEPAS (53.3 mg/kg)

9.55 ± 0.19*

1.85 ± 0.06*

248.01 ± 54.98*

Diabetic + AEPAS (106.6 mg/kg)

10.40 ± 0.14*

2.48 ± 0.17*

120.71 ± 25.87*

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC.
  2. AEPAS: Aqueous extract of P. americana seeds; HOMA-IR: homeostatic model assessment of insulin resistance: [(Fasting serum insulin in U/l *fasting blood glucose in mmol/l)/22.5]; HOMA-β: homeostatic model assessment of β-cell function: [(Fasting serum insulin in U/l *20/fasting blood glucose in mmol/l-3.5)]; conversion factor: insulin (1U/l = 7.174 pmol/l).
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