Table 5 Hepatic antioxidant markers of alloxan-induced diabetic rats after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Groups

Parameters

MDA (nmol/l)

CAT (U/mg protein)

SOD (U/mg protein)

GPX (U/mg protein)

GSH (µmol/mg tissue)

GST (U/mg protein)

Normal control

2.56 ± 0.63

10.22 ± 0.03

8.14 ± 0.01

17.12 ± 0.02

90.08 ± 11.71

11.09 ± 0.24

Diabetic control

6.11 ± 0.66#

1.55 ± 0.03#

0.56 ± 0.03#

4.56 ± 0.34#

42.27 ± 5.43#

0.25 ± 0.02#

Diabetic + metformin

2.49 ± 0.56*

8.12 ± 0.46*

6.14 ± 0.07*

10.99 ± 0.69*

86.33 ± 9.08*

9.78 ± 0.13*

Diabetic + AEPAS (26.7 mg/kg)

3.22 ± 0.54*

5.56 ± 0.09*

4.07 ± 0.02*

7.75 ± 0.14*

73.23 ± 9.08*

6.44 ± 0.09*

Diabetic + AEPAS (53.3 mg/kg)

2.63 ± 0.66*

6.77 ± 0.25*

5.09 ± 0.01*

8.83 ± 0.03*

91.87 ± 9.72*

7.54 ± 0.06*

Diabetic + AEPAS (106.6 mg/kg)

2.02 ± 0.55*

9.15 ± 0.48*

7.15 ± 0.02*

10.13 ± 0.19*

107.43 ± 7.63*

10.03 ± 0.13*

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC.
  2. AEPAS: aqueous extract of P. americana seeds; MDA: malondialdehyde; CAT: catalase; SOD: superoxide dismutase; GPX: glutathione peroxidase; GSH: reduced glutathione; GST: glutathione s-transferase.
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