Table 6 Pancreatic antioxidant markers of alloxan-induced diabetic rats after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Groups

Parameters

MDA (nmol/l)

CAT (U/mg protein)

SOD (U/mg protein)

GPX (U/mg protein)

GSH (µmol/mg tissue)

GST (U/mg protein)

Normal control

1.66 ± 0.14

10.97 ± 0.01

6.34 ± 0.03

2.16 ± 0.02

8.12 ± 0.11

9.38 ± 0.52

Diabetic control

7.75 ± 0.12#

1.16 ± 0.01#

0.12 ± 0.02#

0.02 ± 0.03#

3.12 ± 0.26#

0.16 ± 0.02#

Diabetic + metformin

1.68 ± 0.58*

8.82 ± 0.03*

5.35 ± 0.03*

1.45 ± 0.01*

7.52 ± 0.29*

8.76 ± 0.29*

Diabetic + AEPAS (26.7 mg/kg)

3.56 ± 0.59*

4.46 ± 0.03*

3.22 ± 0.03*

1.23 ± 0.03*

5.69 ± 0.33*

6.37 ± 0.19*

Diabetic + AEPAS (53.3 mg/kg)

2.85 ± 0.27*

6.80 ± 0.03*

4.31 ± 0.03*

1.38 ± 0.01*

6.46 ± 0.25*

7.57 ± 0.21*

Diabetic + AEPAS (106.6 mg/kg)

1.42 ± 0.13*

8.16 ± 0.06*

5.36 ± 0.06*

1.98 ± 0.01*

9.38 ± 0.52*

8.11 ± 0.39*

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC.
  2. AEPAS: aqueous extract of P. americana seeds; CAT: catalase; SOD: superoxide dismutase; GPX: glutathione peroxidase; GSH: reduced glutathione; GST glutathione s-transferase; MDA: malondialdehyde.
Back to article page