Table 7 Lipid profile of alloxan-induced diabetic rats after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Groups

Parameters

TC (mmol/l)

HDL-c (mmol/l)

TG (mmol/l)

VLDL-c (mmol/l)

LDL-c (mmol/l)

AI

CRI

Normal control

38.63 ± 2.53

30.11 ± 3.27

27.97 ± 1.29

5.59 ± 0.26

2.92 ± 1.81

0.22 ± 0.04

1.30 ± 0.07

Diabetic control

103.97 ± 4.33#

6.74 ± 0.27#

73.63 ± 0.15#

14.73 ± 0.03#

82.50 ± 4.03#

0.94 ± 0.00#

15.42 ± 0.02#

Diabetic + metformin

66.02 ± 5.07*

21.07 ± 0.39*

63.85 ± 0.30*

12.77 ± 0.06*

32.18 ± 5.25*

0.68 ± 0.03*

3.14 ± 0.27*

Diabetic + AEPAS (26.7 mg/kg)

49.17 ± 0.32*

24.27 ± 0.18*

53.21 ± 0.12*

10.64 ± 0.02*

14.26 ± 0.47*

0.51 ± 0.01*

2.03 ± 0.03*

Diabetic + AEPAS (53.3 mg/kg)

44.43 ± 0.92*

26.09 ± 0.03*

42.96 ± 0.04*

8.59 ± 0.01*

9.74 ± 0.94*

0.41 ± 0.01*

1.70 ± 0.04*

Diabetic + AEPAS (106.6 mg/kg)

38.52 ± 0.50*

28.80 ± 0.21*

34.96 ± 2.15*

6.99 ± 0.43*

2.73 ± 0.83*

0.25 ± 0.01*

1.34 ± 0.03*

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC.
  2. AEPAS: Aqueous extract of P. americana seeds; TC: total cholesterol; TG: triglyceride; HDL-c: high density lipoprotein-cholesterol; AI: atherogenic index: [(TC-HDL-c)/HDL-c]; CRI: coronary index: [(TC(mg/dl)/HDL-c(mg/dl)]; VLDL-c: very low density lipoprotein-cholesterol: [TG/5]; LDL-c: low density lipoprotein-cholesterol: [TC-HDL-(TG/5)].
Back to article page