Table 8 Hepatic glycogen and carbohydrate metabolizing enzyme levels after oral administration of aqueous extract of P. americana seeds.

From: Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Treatment groups

Hepatic glycogenα

Hexokinaseβ

Fructose-1,6-bisphosphataseγ

Glucose-6-phosphataseγ

Normal control

53.20 ± 1.15

1.52 ± 0.50

1.28 ± 0.04

22.61 ± 1.42

Diabetic control

15.84 ± 3.50#

0.26 ± 0.04#

3.21 ± 0.32#

94.73 ± 2.47#

Diabetic + metformin

55.98 ± 2.16*

1.11 ± 0.07*

0.87 ± 0.03*

60.88 ± 2.31*

Diabetic + AEPAS (26.7 mg/kg)

54.84 ± 0.86*

0.76 ± 0.13*

0.94 ± 0.07*

53.98 ± 1.87*

Diabetic + AEPAS (53.3 mg/kg)

55.27 ± 0.57*

1.14 ± 0.07*

0.99 ± 0.11*

47.36 ± 1.32*

Diabetic + AEPAS (106.6 mg/kg)

92.05 ± 3.93*

1.31 ± 0.07*

1.13 ± 0.10*

36.90 ± 3.76*

  1. Data are expressed as mean ± SEM (n = 6). *Statistically significant (p < 0.05) to DC; #Statistically significant (p < 0.05) to NC.
  2. AEPAS: Aqueous extract of P. americana seeds; α: Unit for glycogen (mg of glucose/g of wet tissue); β: Unit for hexokinase (µmole glucose-6-phosphate formed/min/mg protein); γ: Unit for fructose-1,6-bisphosphatase and glucose-6-phosphatase (µmole phosphate liberated/min/mg protein).
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