Figure 1

Effect of monoamine transporter drugs on DAT-KO hyperactivity. Hyperactive DAT-KO mice were systemically injected with vehicle (saline) or the transporter blockers desipramine (NET) (i.p.) or fluoxetine (SERT) (s.c). (A) Locomotor activity (cm/5 min) was recorded for 120 min, preceded by a 30 min baseline recording. (B) Total distance traveled for baseline (cm/30 min) and post-injections sessions (cm/120 min) were calculated. N = 6–12 mice per group. F (2, 26) = 23.44, *P < 0.05, ****P < 0.0001 using two-way ANOVA, compared to Vehicle-treated controls, ns- not significant.