Figure 4

Effect of PFC infusion of monoamine transporter drugs on DAT-KO hyperactivity. (A) Hyperactive DATKO mice were infused (drug infusion PFC) with vehicle (aCSF) or 4ug/0.5ul of desipramine or fluoxetine (dissolved in aCSF) in the PFC, after a 30 min baseline, and locomotor activity (cm/5 min) was recorded for 120 min post-infusion. (B) Baseline (cm/30 min) and post-infusion (cm/120 min) total distance traveled was measured upon local infusion of desipramine, amphetamine (AMPH) or fluoxetine. n = 6–8 mice per group. Pairwise comparisons using Two-way ANOVA, F (4, 52) = 2.973 *p < 0.05, ns not significant.