Figure 3
From: Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo
Neu2 Deficiency affects sialylated glycoproteins regulating lipid metabolism and muscle function. (a) A heat map of the identified sialylated glycoproteins in the liver and EDL muscle. Glycoprotein intensity analysis and T-test were performed using an in-house program coded by Python 3.8 with the SciPy Stats module, while the heat map was drawn using the Seaborn Clustermap module. (b) Biological process enrichment analysis showed identification of sialylated glycoproteins involved in lipid metabolism and muscle functionality. All studies were conducted in control and Neu2 KO littermates 25 weeks of age. WT: n = 1; Neu2 KO: n = 1. Data are obtained in triplicate experiments.
