Table 1 Identification of sialylated glycoproteins involved in lipid metabolism and muscle function.
From: Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo
Organ | Gene Symbol | Glycoprotein | Function | Overall sialylation expression pattern |
|---|---|---|---|---|
Liver | Apob | Apolipoprotein B-100 | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor | Down |
Hsd17b7 | 3-keto-steroid reductase | Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis | Down | |
Mia3 | Transport and Golgi organization protein 1 homolog (TANGO1) | Required for secretion of lipoproteins by participating in their export from the endoplasmic reticulum | Down | |
Pon1 | Serum paraoxonase | Major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis | Down | |
Apoh | Beta-2-glycoprotein 1 | Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate | Down | |
Abcc2 | Canalicular multispecific organic anion transporter 1 | Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid, and leukotriene C4 | Down | |
Scarb2 | Lysosome membrane protein 2 | Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | Down | |
G6pc | Glucose-6-phosphatase | Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT). This complex is responsible for glucose production through glycogenolysis and gluconeogenesis. It is the key enzyme in homeostatic regulation of blood glucose level | Up | |
EDL | Fmod | Fibromodulin | Affects the rate of fibril formation. Might have a primary role in collagen fibrillogenesis | Up |
Myorg | Myogenesis-regulating glycosidase | Promotes myogenesis by activating AKT signaling through maturation and secretion of IG | Up | |
Dcn | Decorin | Affects the rate of fibril formation | Up | |
Trdn | Triadin | Contributes to regulation of luminal Ca2 + release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction | Up | |
Atp1b2 | Sodium/potassium -transporting ATPase subunit beta-2 | The non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na + and K + ions across the plasma membrane | Up | |
Tf | Serotransferrin | An iron binding transport protein that can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate | Up |
