Figure 3
From: Grey matter correlates of affective and somatic symptoms of premenstrual dysphoric disorder
Correlation of GMV within ROI by PMDD symptom severity. (a) Correlation between DRSP scores corresponding to PMDD symptoms as defined by the DSM-V domains, and raw grey matter volume (GMV) within the cortical, and subcortical ROIs. The colors represent the correlation coefficient values. Positive and negative correlations are illustrated in red and blue respectively. ⎕, p < 0.05 after correcting for TIV, age and BMI. Rectangles including left and right ROIs indicate significant correlations obtained for the bilateral average ROI. The correlation heatmap was generated using JMP10 (JMP, SAS Institute). (b) Scatterplots depicting the correlations between GMV of the left and right amygdala (raw values, unadjusted for TIV, age and BMI) and the total DRSP score, as well as the scores of the PMDD domains affective lability, depression, anhedonia, concentration, energy loss, sleep and overwhelmed (− 0.33 < r < − 0.29). Dotted lines indicate non-significant correlations. ACC anterior cingulate cortex, AMY amygdala, DRSP Daily Record of Severity of Problems, HC hippocampus, INS insula, L left, MFG middle frontal gyrus, OFC orbitofrontal cortex, R right, SFG superior frontal gyrus, VERMIS cerebellar vermis.
