Table 1 Patients’ clinical and metabolic parameters at the diagnosis and at the beginning of the therapy.

From: Computed tomography based analyses of body mass composition in HER2 positive metastatic breast cancer patients undergoing first line treatment with pertuzumab and trastuzumab

 

N (%)

Parameters at the diagnosis

Age median (inter quartile range)

54 (47–61)

Menopausal status

Pre 10 (23.3)

Post 33 (76.7)

Histology

Ductal 36 (83.7)

Lobular 2 (4.7)

Other 5 (11.6)

Stage

I-III 25 (58.1)

IV 18 (41.9)

Surgery

No 11 (26.8)

Yes 30 (73.2)

Er (%)

Negative (0) 15 (34.9)

Positive (≥ 1) 28 (65.1)

PgR(%)

Low (≤ 20) 30 (69.8)

High (> 20) 13 (30.2)

Ki67 (%)

Low (≤ 20) 9 (21.9)

High (> 20) 32 (78.1)

Missing 2

Parameters at the beginning of the therapy

Age

58 (52–64)

Weight median (inter quartile range)

65 (59–74)

ECOG performance status

0 39 (90.7)

1–2 4 (9.3)

BMI

 < 25 21 (48.8)

25–30 16 (37.2)

 > 30 6 (14.0)

Body composition parameters

Median (inter quartile range)

SM (skeletal muscle; cm2)

110.18 (97.43–124.58)

SF (subcutaneous fat; cm2)

225.06 (150.93–285.02)

VF (visceral fat; cm2)

93.77 (44.47–140.79)

TAFT (Total abdominal fat; cm2)

299.11 (222.28–399.89)

SMI (skeletal muscle index; cm2/m2)

42.26 (36.02–45.04)

SFI (subcutaneous fat index; cm2/m2)

82.97 (55.68–118.63)

VFI (visceral fat index; cm2/m2)

37.10 (18.04–60.14)

TAFTI (Total abdominal fat index; cm2/m2)

118.82 (86.54–157.39)