Table 1 Novel genes targeting pirfenidone, nintedanib, or both pirfenidone and nintedanib.

From: Integrated bioinformatics analysis identifies established and novel TGFβ1-regulated genes modulated by anti-fibrotic drugs

Gene name

Gene

Blue module membership

Pirfenidone only

Brain abundant membrane attached signal protein 1

BASP1

0.76

Hydroxysteroid 17-beta dehydrogenase 6

HSD17B6

0.99

Cadherin 11

CDH11

0.92

Tensin 1

TNS1

0.93

Nintedanib only

Clathrin interactor 1

CLINT1

0.97

Cell adhesion molecule 1

CADM1

0.95

Metadherin

MTDH

0.90

Synapse defective rho GTPase homolog 1

SYDE1

0.70

MCTS1 re-initiation and release factor

MCTS1

0.62

Pirfenidone and nintedanib

Myeloid derived growth factor

MYDGF

0.94

  1. Novel is defined as not previously identified in known TGFβ1 signaling pathways.
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