Table 1 Baseline characteristics of the 25 participants.

From: Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study

 

N

Mean (SD) or frequency (%)

Age—years

25

12.3 (3.5)

Female sex

16

64%

White race

24

96%

Non-Hispanic ethnicity

20

80%

Sibling age at T1D diagnosis—years

25

7.4 (3.8)

Number of first-degree relatives with T1D

1

22

88%

 ≥ 2

3

12%

BMI Z-score

25

0.43 (1.09)

Pubertal stageA

Pre-pubertal

10

40%

Early/mid-pubertal

5

20%

Late/post-pubertal

10

40%

HLA genotype

Non-DR3 and non-DR4

15

60%

DR3 and/or DR4

10

40%

Number of positive autoantibodies

0

19

76%

1

2

8%

 ≥ 2

4

16%

Positive autoantibodies

GAD65

6

24%

IA-2

2

8%

IAA

1

4%

ZnT8

4

16%

  1. Pre-pubertal is defined as Tanner stage 1; mid-pubertal is defined as Tanner stage 2–3; late/post-pubertal is defined as Tanner stage 4–5.
  2. APubertal staging was performed by a pediatric endocrinologist.