Figure 4
Exploratory analysis of the DEGs in LGG cases with high versus low DMD expression. (a) Volcano and M-A plots of the log fold change of all genes. Upregulated and downregulated genes are indicated by red and blue points respectively. (b) STRING PPI network of DEGs with 60 edges (versus 20 expected) and an enrichment P value of 7.92e−13. Edge thickness indicates confidence, disconnected nodes are hidden. (c) Identification of significant hub genes from DEGs using the Cytohubba MCC and DMNC algorithms within Cytoscape. Colour represents ranking based on corrected P values from red to yellow, the expanded subnetwork is displayed by blue nodes. (d) Venn analysis of both sets of hub genes reveals 13 common significant hub genes. (e) Network tree visualisation of the enriched pathways in DEGs using the GO biological processes annotation, dot size corresponds to adjusted P values. (f) Visualisation of the relationship among enriched GO categories. Connected gene sets share more genes, colour of node represents adjusted P values.
