Figure 5
From: The metabolism of cells regulates their sensitivity to NK cells depending on p53 status
Decreasing p53 levels diminishes the DCA-induced increase in cytotoxicity. OCI-AML3 cells were treated as in Fig. 4 and then incubated overnight with e-NK cells at different E:T ratios. The specific killing of tumor cells was quantified by FACs. The data represent means ± SD of 3 independent experiments; *p < 0.001; 2way Anova compared to cells non-treated with eNK or against cells non-treated with DCA (depicted in the graphic); #p < 0.001; 2 way Anova compared to cells transfected with siCtrl.
