Table 1 eQTL SNPs displaying congruent association with adipocyte lipolysis and BMI.

From: Shared genetic loci for body fat storage and adipocyte lipolysis in humans

SNP

Chrom

Pos

Spontaneous lipolysis

BMI

eQTL (SAT)

Detected in hASCs

Beta

p

Ref

Alt

Freq

Beta

p

Ref

Alt

Freq

Gene

p

High

Low

rs967605

1

23399932

0.07

7.78E−03

T

C

0.14

− 0.02

3.68E−13

C

T

0.83

ZNF436

0.0000086

C

T

Yesa

             

ZNF436-AS1

0.000018

C

T

n.d

rs10923724

1

119546842

0.05

8.33E−03

T

C

0.40

− 0.01

1.14E−12

C

T

0.57

WARS2

1.70E−46

C

T

Yesa

             

TBX15

0.0000097

T

C

Yesa

rs919433

2

198166565

− 0.04

2.67E−02

A

G

0.62

0.01

1.36E−11

G

A

0.36

ANKRD44

7.30E−13

G

A

n.d

rs4515655

9

128616073

− 0.04

4.37E−02

C

T

0.38

− 0.01

1.01E−09

C

T

0.40

PBX3

3.10E−17

T

C

n.d

rs17105272

14

77529783

− 0.04

4.15E−02

T

C

0.67

0.01

2.22E−09

C

T

0.32

RP11-7F17.3

4.20E−09

T

C

n.d

SNP

Chrom

Pos

Isoprenaline stimulated lipolysis

BMI

eQTL (SAT)

Detected in hASCs

Beta

p

Ref

Alt

Freq

Beta

p

Ref

Alt

Freq

GENE

p

High

Low

rs967605

1

23399932

− 0.06

1.63E−03

T

C

0.14

− 0.02

3.68E−13

C

T

0.83

ZNF436

8.60E−06

C

T

Yesa

             

ZNF436-AS1

1.80E−05

C

T

n.d

rs2850969

4

102183594

0.04

2.81E−02

C

T

0.85

− 0.01

2.16E−09

C

T

0.86

FLJ20021

1.90E−11

T

C

Yesa

rs450231

9

101481205

− 0.03

2.76E−02

A

G

0.29

− 0.01

2.59E−12

G

A

0.75

ANKS6

0.000065

G

A

n.d

rs10118701

9

103061366

0.04

1.02E−02

G

A

0.66

− 0.01

3.46E−12

G

A

0.68

INVS

1.70E−13

G

A

Yesa

             

STX17

1.50E−07

G

A

Yesa

rs4515655

9

128616073

0.03

4.34E−02

C

T

0.38

− 0.01

1.01E−09

C

T

0.40

PBX3

3.10E−17

T

C

n.d

rs3781099

10

27318776

0.05

4.67E−02

T

C

0.92

0.02

8.07E−11

C

T

0.08

MASTL

4.20E−11

C

T

n.d

             

LINC00202-1

0.0000022

T

C

n.d

rs1558236

12

111780998

− 0.09

2.09E−02

G

C

0.97

0.06

9.85E−15

G

C

0.97

ALDH2

0.0000018

G (rare)

C

Yesa

rs2537847

17

65694355

0.03

3.14E−02

G

A

0.25

− 0.01

3.39E−09

G

A

0.24

RP11-855A2.1

0.000071

A

G

n.d

  1. Where Chrom. chromosome, Pos. genome position in basepairs according to GRCh37, Beta refer to Alt allele, Freq frequency of Alt allele, High allele with highest gene expression according to GTEx; n.d. = mRNA not detected in hASC undergoing in vitro differentiation to adipocytes.
  2. aExpression is presented in the Supplementary Fig. 1.
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