Table 3 Gene sets overrepresented among ZNF436 or NUP85 regulated genes.
From: Shared genetic loci for body fat storage and adipocyte lipolysis in humans
GeneSet | Description | Expected number of genes | Enrichment ratio | p | FDR | Gene symbols |
|---|---|---|---|---|---|---|
Gene sets overrepresented among genes downregulated by by ZNF436 knockdown | ||||||
GO:0062012 | Regulation of small molecule metabolic process | 3 | 4 | 3.49E−05 | 0.03 | FABP3;IGF1;SQLE;ENO1;IDI1;ABCD2;MVD;FDPS;GPER1;KAT2A;HMGCR;HMGCS1;STARD4 |
GO:0008202 | Steroid metabolic process | 3 | 4 | 1.02E−04 | 0.04 | DHCR24;AGT;SQLE;IDI1;MVD;FDPS;ACAT2;HMGCR;CYP4V2;HMGCS1;STARD4 |
GO:1901615 | Organic hydroxy compound metabolic process | 4 | 3 | 1.54E−04 | 0.04 | DHCR24;IGF1;SQLE;IDI1;PLCB2;MVD;FDPS;GPER1;ACAT2;HMGCR;CYP4V2;HMGCS1;PCBD1;STARD4 |
GO:0035051 | Cardiocyte differentiation | 1 | 5 | 3.19E−04 | 0.06 | AGT;IGF1;HAMP;GPER1;KAT2A;TBX3;MYLK3 |
GO:0019216 | Regulation of lipid metabolic process | 4 | 3 | 3.60E−04 | 0.06 | FABP3;AGT;PDE3B;SQLE;IDI1;ABCD2;MVD;FDPS;GPER1;HMGCR;HMGCS1;STARD4 |
GO:0006720 | Isoprenoid metabolic process | 1 | 6 | 4.61E−04 | 0.07 | IDI1;MVD;FDPS;HMGCR;CYP4V2;HMGCS1 |
Gene sets overrepresented among genes upregulated by ZNF436 knockdown | ||||||
GO:0045926 | Negative regulation of growth | 3 | 4 | 1.74E−05 | 0.01 | MT1F;MT1E;MT1M;DNAJB2;MT1A;MT2A;MT1G;DUSP10;MT1H;SEMA3A;SEMA7A;SOCS2 |
GO:0055076 | Transition metal ion homeostasis | 2 | 5 | 4.49E−05 | 0.02 | MT1F;MT1E;MT1M;MT1A;MT2A;MT1G;ABCB6;MT1H;PICALM |
GO:0097485 | Neuron projection guidance | 3 | 4 | 2.64E−04 | 0.06 | NEXN;FEZ1;EZR;FAM129B;SEMA3A;CHN1;PALLD;GAB1;SEMA7A;VASP |
GO:0090066 | Regulation of anatomical structure size | 5 | 3 | 2.79E−04 | 0.06 | PREX1;EZR;ARPC1B;PFN2;LRRC8A;GCLM;ANXA7;ACTA2;SEMA3A;TMOD3;PICALM;ADRA1B;SEMA7A;TMOD2;VASP |
Gene sets overrepresented among genes downregulated by NUP85 knockdown | ||||||
GO:0043062 | Extracellular structure organization | 8 | 5 | 7.77E-16 | 6.60E-13 | TNC;SERPINE1;LOX;THBS1;CD34;PTX3;COL11A1;RGCC;FBLN5;FBN2;JAM2;DPT;ITGA11;COL1A1;CRISPLD2;CREB3L1;ENG;SDC1;NDNF;EFEMP2;NID1;LOXL3;AGTR1;BMP1;ERO1B;COL8A1;POSTN;FLRT2;RAMP2;SERPINH1;FBN1;PLOD3;CAPG;CD44;SMAD3;APBB2;PLOD1;COLGALT1 |
GO:0007162 | Negative regulation of cell adhesion | 5 | 3 | 1.03E-05 | 1.09E-03 | TNC;SERPINE1;THBS1;RGCC;JAM2;COL1A1;IL20RB;MYADM;LOXL3;FAM107A;PLXNA2;CASP3;SNAI2;DUSP1;POSTN;ARG2;ANGPT1 |
GO:0045444 | Fat cell differentiation | 5 | 3 | 6.43E-04 | 1.40E-02 | WNT5A;LEP;TGFB1I1;GPX1;CCND1;JDP2;SNAI2;FRZB;WNT5B;SMAD3;GPER1;CCDC3;ADRB1 |
GO:0019216 | Regulation of lipid metabolic process | 8 | 2 | 0.006998547 | 7.82E-02 | PDGFRB;LEP;DKK3;LPGAT1;DHCR7;EGR1;FDPS;TXNRD1;IGFBP7;SNAI2;AGTR1;ADIPOR2;CNR1;GPER1;FHL2;CCDC3 |
