Figure 7
From: Evaluation of phototoxicity induced by the anticancer drug rucaparib
Relative fluorescence of rhodamine 110 (λexc = 485 nm, λem = 528 nm) after caspase-3/7 activation assay by cells treated with rucaparib (RCP). Cells unexposed (HaCaT) or treated with 0.25, 1 or 3 μM of RCP were kept on dark conditions (■) or irradiated at a 5 J/cm2 UVA dose (□) and subsequently incubated with Z-DEVD-R110 for 4 h. Data represent mean ± SD of two independent experiments performed in triplicate upon dark or UVA light conditions. Asterisks indicate significant differences by Student’s t test (**p < 0.001, *p < 0.05). Data were analyzed using GraphPad Prism v5.03.
