Table 2 Brain penetrating properties of BAY-747 and runcaciguat.

From: The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

 

LC–MS/MS analyses

Whole-body autoradiography (based on AUC)

BAY-747

Brain:plasma ratio

0.60 (2.0)

Brain:plasma ratio

0.38

Brain:blood ratio

0.60

Blood:plasma ratio

1.59

Runcaciguat

Brain:plasma ratio

0.10 (1.40)

Brain:plasma ratio

0.13

Brain:blood ratio

0.20

Blood:plasma ratio

0.68

  1. Described is the brain:plasma ratio of BAY-747 and runcaciguat measured with LC–MS/MS [displayed as gMean (gSD)] and measured with whole-body autoradiography. A brain:plasma ratio > 0.04 is generally considered as good brain penetration. The blood to plasma ratio is determined to calculate from blood to plasma partitioning of the compounds.
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