Figure 6

Directionality of dense clusters. (A) Distributions of the differences in ELs between down- and upstream editing sites in two-adenine (AA) dense clusters. Three asterisks mark statistical significance of the differences in means (p < 0.001, the χ² contingency test). (B) Differences between the probabilities of down- and upstream editing sites to be non-synonymous. Three asterisks mark statistical significance of the differences in means (p < 0.001, the binomial test). (C) Differences in base-pairing probabilities between paired editing sites (EE) and three types of control AA-dinucleotides (see the text for details). Red color of a letter indicates the nucleotide in a dinucleotide, for which base-pairing probabilities are considered. Red and blue circles show significantly lower and higher base-pairing probabilities for the EE dinucleotide compared to the respective control (the Wilcoxon test p < 0.05, Bonferroni corrected).