Figure 1
From: miR-96-5p targets PTEN to mediate sunitinib resistance in clear cell renal cell carcinoma
Upregulation of miR-96-5p in tumors from sunitinib-resistant clear cell renal cell carcinoma (CCRCC) patients. (a) Volcano plot of differentially expressed miRNAs from microarray of sunitinib-resistant and sunitinib-sensitive CCRCC patients. (b) Heatmap of 18 miRNAs differentially expressed in resistant samples compared with sensitive samples in tumors. (c) Schematics of target prediction and pathway analysis with differentially expressed miRNAs presented in (a) and (b). (d) Predicted common targets of differentially expressed miRNAs were subjected to Ingenuity Pathway Analysis (IPA), and the top 20 enriched canonical pathways are shown (red bars: pathways directly correlated with cancer; blue bars: pathways of organismal growth and development; green bars: pathways of cellular growth, proliferation, and development). (e) A heatmap of the cellular and biofunctions enriched in resistant samples compared with sensitive samples. Orange (positive z-score) or blue (negative z-score) color codes represent the activation or inhibition of the given cellular functions.
