Table 3 Risk factors for slower progression to AIDSAD in Chinese patients.

From: CRF07_BC is associated with slow HIV disease progression in Chinese patients

 

Number of sequences

AIDSAD prevalencea

Univariable analysisb

Multivariable analysisc

OR(95% CI)

P value

OR(95% CI)

P value

Sex

Men

9681

2210(22.83)

Reference

   

Women

758

210(27.7)

1.29(1.1–1.53)

0.002

0.86(0.71–1.04)

0.12

Age at diagnosis(years) group

 < 18

48

10(20.83)

Reference

   

18–24

1625

207(12.74)

0.55(0.12–1.19)

0.1

1.11(0.48–2.94)

0.82

25–44

6559

1463(22.31)

1.09(0.28–2.32)

0.81

2.05(0.9–5.4)

0.11

45–64

1962

648(33.03)

1.87(0.56–4)

0.08

3.36(1.47–8.87)

0.007

 ≥ 65

240

91(37.92)

2.32(1.14–5.13)

0.03

4.32(1.81–11.75)

0.002

Ethnicity

Han

9879

2310(23.38)

Reference

   

Uyghur

97

8(8.25)

0.29(0.13–0.57)

 < 0.001

0.49(0.21–1.02)

0.08

Yi

90

7(7.78)

0.28(0.12–0.56)

0.001

0.43(0.17–0.9)

0.04

Other

373

95(25.47)

1.12(0.88–1.41)

0.35

1.18(0.92–1.5)

0.19

Transmission risk group

Heterosexual

2855

841(29.46)

Reference

   

MSM

7086

1454(20.52)

0.62(0.56–0.68)

 < 0.001

0.67(0.6–0.75)

 < 0.001

Injecting drug user

312

51(16.35)

0.47(0.34–0.63)

 < 0.001

0.85(0.59–1.2)

0.36

Blood transfusion

112

51(45.54)

2(1.36–2.93)

 < 0.001

1.86(1.24–2.79)

0.003

Mother to child

10

4(40)

1.6(0.41–5.6)

0.47

3.36(0.7–15.3)

0.12

Subtype

B

1508

452(29.97)

Reference

   

C

72

20(27.78)

0.9(0.51–1.5)

0.69

0.82(0.47–1.39)

0.48

01_AE

4819

1259(26.13)

0.83(0.73–0.94)

0.003

0.94(0.82–1.07)

0.35

07_BC

2815

421(14.96)

0.41(0.35–0.48)

 < 0.001

0.46(0.39–0.53)

 < 0.001

08_BC

95

29(30.53)

1.03(0.65–1.59)

0.91

0.83(0.51–1.3)

0.42

55_01B

169

41(24.26)

0.75(0.51–1.07)

0.12

0.78(0.53–1.13)

0.2

URF

708

142(20.06)

0.59(0.47–0.72)

 < 0.001

0.62(0.5–0.78)

 < 0.001

Minor

253

56(22.13)

0.66(0.48–0.91)

0.01

0.63(0.45–0.86)

0.005

Region

North

5061

1191(23.53)

Reference

   

North-east

1486

338(22.75)

0.96(0.83–1.1)

0.53

  

East

1251

293(23.42)

0.99(0.86–1.15)

0.93

  

Central-south

1324

313(23.64)

1(0.87–1.16)

0.93

  

South-west

752

168(22.34)

0.93(0.78–1.12)

0.47

  

North-west

542

110(20.3)

0.83(0.66–1.03)

0.09

  

Sampling phase

1994–2005

71

20(28.17)

Reference

   

2006–2008

574

133(23.17)

0.77(0.45–1.36)

0.35

  

2009–2011

1537

372(24.2)

0.81(0.49–1.41)

0.45

  

2012–2014

2562

516(20.14)

0.64(0.39–1.11)

0.1

  

2015–2017

3101

735(23.7)

0.79(0.48–1.37)

0.38

  

2018–2020

2594

644(24.83)

0.84(0.51–1.45)

0.52

  
  1. AIDSAD, AIDS at diagnose; OR, odds ratio; MSM, men who have sex with men; URF, unique recombinant form;
  2. North, Beijing, Tianjin, Hebei, Shanxi, and Inner Mongolia. North-east, Liaoning, Jilin, and Heilongjiang. East, Shanghai, Jiangsu, Zhejiang, Anhui, Fujian, Jiangxi, and Shandong. Central- south, Henan, Hubei, Hunan, Guangdong, Guangxi, and Hainan. South-west, Chongqing, Sichuan, Guizhou, Yunnan, and Tibet. North-west, Shann'xi, Gansu, Qinghai, Ningxia, and Sinkiang.
  3. Minor, A1, D, F1, G, H, CRF02_AG, CRF03_AB, CRF06_cpx, CRF15_01B, CRF18_cpx, CRF24_BG, CRF33_01B, CRF55_01B, CRF57_BC, CRF58_01B, CRF59_01B, CRF61_BC, CRF62_BC, CRF63_02A1, CRF64_BC, CRF65_cpx, CRF67_01B, CRF68_01B, CRF78_cpx, CRF79_0107, CRF82_cpx, CRF83_cpx, CRF85_BC, CRF86_BC, CRF87_cpx, CRF88_BC, and CRF96_cpx.
  4. aData are n(%).
  5. bUnivariable logistic regression analysis.
  6. cMultivariable logistic regression analysis.
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