Table 5 Change in IDPs between the first and second imaging visits. Values are reported as mean and standard deviation. An asterisk (*) indicates the p-value is below the significance threshold adjusted for multiple comparisons. ASAT: abdominal subcutaneous adipsose tissue; Conc: concentration; CSA: cross-sectional area; PDFF: proton density fat fraction; VAT: visceral adipose tissue.
Women | Men | |||||||
|---|---|---|---|---|---|---|---|---|
N | Difference | %-diff | p-value | N | Difference | %-diff | p-value | |
Liver Volume (ml) | 1462 | \(-4.05 \pm 101.98\) | \(-0.11 \pm 7.50\) | 0.0228 | 1453 | \(-14.45 \pm 136.47\) | \(-0.64 \pm 8.59\) | \(1.1\times 10^{-05}\)* |
Lungs Volume (ml) | 1462 | \(-12.34 \pm 257.82\) | \(0.21 \pm 11.01\) | 0.3546 | 1452 | \(-12.61 \pm 395.84\) | \(0.46 \pm 12.66\) | 0.9522 |
Pancreas Volume (ml) | 1364 | \(-1.14 \pm 10.12\) | \(-0.47 \pm 19.41\) | \(3.1\times 10^{-06}\)* | 1352 | \(-1.26 \pm 9.48\) | \(-0.56 \pm 18.15\) | \(2.1\times 10^{-09}\)* |
Left Kidney Volume (ml) | 1462 | \(-0.85 \pm 11.59\) | \(-0.16 \pm 10.92\) | 0.00084 | 1450 | \(-2.47 \pm 11.49\) | \(-1.37 \pm 8.94\) | \(4.8\times 10^{-18}\)* |
Right Kidney Volume (ml) | 1461 | \(-0.70 \pm 10.48\) | \(-0.23 \pm 8.42\) | 0.0046 | 1451 | \(-1.75 \pm 11.55\) | \(-0.97 \pm 7.79\) | \(7.5\times 10^{-11}\)* |
Spleen Volume (ml) | 1459 | \(-2.60 \pm 18.39\) | \(-1.03 \pm 12.92\) | \(9.1\times 10^{-12}\)* | 1450 | \(-2.83 \pm 23.71\) | \(-1.01 \pm 11.92\) | \(8.1\times 10^{-10}\)* |
ASAT Volume (ml) | 1462 | \(39.66 \pm 1,391.39\) | \(1.57 \pm 15.60\) | 0.0116 | 1453 | \(32.80 \pm 1,113.74\) | \(2.30 \pm 20.93\) | 0.0038 |
VAT Volume (ml) | 1462 | \(71.24 \pm 467.64\) | \(5.09 \pm 23.50\) | \(9\times 10^{-17}\)* | 1455 | \(65.20 \pm 837.55\) | \(3.06 \pm 20.40\) | \(1.6\times 10^{-08}\)* |
Total Thigh Subcutaneous Fat (ml) | 1462 | \(-35.86 \pm 991.81\) | \(0.06 \pm 10.48\) | 0.3256 | 1453 | \(38.67 \pm 748.45\) | \(1.47 \pm 12.96\) | 0.00036 |
Total Thigh Internal Fat Volume (ml) | 1462 | \(7.94 \pm 63.35\) | \(1.47 \pm 9.77\) | \(1.5\times 10^{-08}\)* | 1453 | \(38.98 \pm 100.75\) | \(6.38 \pm 15.17\) | \(8.4\times 10^{-51}\)* |
Total Muscle Volume (ml) | 1462 | \(-139.34 \pm 488.70\) | \(-0.87 \pm 3.19\) | \(9.4\times 10^{-26}\)* | 1453 | \(-421.40 \pm 738.52\) | \(-1.83 \pm 3.23\) | \(2.4\times 10^{-94}\)* |
Total Iliopsoas Muscle Volume (ml) | 1460 | \(-7.56 \pm 19.24\) | \(-1.46 \pm 3.90\) | \(1.2\times 10^{-50}\)* | 1449 | \(-16.76 \pm 30.67\) | \(-2.13 \pm 3.95\) | \(6.7\times 10^{-85}\)* |
Total Paraspinal Muscle CSA (\(\text {mm}^2\)) | 1451 | \(-28.19 \pm 184.42\) | \(-0.79 \pm 19.96\) | \(2.9\times 10^{-12}\)* | 1446 | \(-57.85 \pm 249.19\) | \(-2.55 \pm 17.08\) | \(1.4\times 10^{-23}\)* |
Total Thigh Muscle Volume (ml) | 1462 | \(-96.60 \pm 237.07\) | \(-1.37 \pm 3.42\) | \(2.2\times 10^{-55}\)* | 1453 | \(-155.39 \pm 404.74\) | \(-1.46 \pm 3.96\) | \(1.4\times 10^{-53}\)* |
Heart Volume (ml) | 1462 | \(-0.51 \pm 33.09\) | \(0.02 \pm 7.81\) | 0.5244 | 1452 | \(2.01 \pm 46.75\) | \(0.63 \pm 8.12\) | 0.2002 |
Superior Vena Cava CSA (\(\text {mm}^2\)) | 1344 | \(3.67 \pm 111.12\) | \(3.20 \pm 27.13\) | 0.3078 | 1345 | \(-4.01 \pm 116.44\) | \(1.69 \pm 25.39\) | 0.237 |
Descending Suprarenal Aorta CSA (\(\text {mm}^2\)) | 1432 | \(8.44 \pm 64.75\) | \(2.12 \pm 11.79\) | \(1.4\times 10^{-08}\)* | 1435 | \(10.34 \pm 76.36\) | \(2.09 \pm 11.23\) | \(2.8\times 10^{-09}\)* |
Descending Thoracic Aorta CSA (\(\text {mm}^2\)) | 1433 | \(13.97 \pm 58.24\) | \(2.99 \pm 11.01\) | \(5.2\times 10^{-21}\)* | 1435 | \(19.20 \pm 72.00\) | \(3.38 \pm 11.16\) | \(5.6\times 10^{-29}\)* |
Aortic Arch CSA (\(\text {mm}^2\)) | 1363 | \(8.82 \pm 199.84\) | \(4.11 \pm 25.53\) | 0.098 | 1262 | \(23.36 \pm 215.03\) | \(5.13 \pm 24.54\) | \(9.9\times 10^{-05}\)* |
Descending Infrarenal Aorta CSA (\(\text {mm}^2\)) | 1410 | \(4.03 \pm 63.42\) | \(2.57 \pm 17.92\) | 0.0062 | 1421 | \(6.08 \pm 64.13\) | \(2.90 \pm 16.64\) | \(1.3\times 10^{-05}\)* |
Median Liver Iron Conc (mg/g) | 1453 | \(0.0043 \pm 0.21\) | \(1.88 \pm 21.21\) | 0.986 | 1449 | \(0.02 \pm 0.21\) | \(2.53 \pm 17.74\) | 0.00017* |
Median Pancreas Iron Conc (mg/g) | 1241 | \(-0.0064 \pm 0.12\) | \(0.31 \pm 15.23\) | 0.0551 | 1254 | \(0.0036 \pm 0.09\) | \(1.07 \pm 12.71\) | 0.8447 |
Median Paraspinal Muscle Iron Conc (mg/g) | 1451 | \(-0.0086 \pm 0.15\) | \(-0.06 \pm 11.51\) | 0.0357 | 1446 | \(-0.0032 \pm 0.12\) | \(0.12 \pm 9.13\) | 0.2612 |
Median Spleen Iron Conc (mg/g) | 1356 | \(0.00043 \pm 0.25\) | \(3.50 \pm 28.11\) | 0.7197 | 1301 | \(0.02 \pm 0.24\) | \(4.26 \pm 26.61\) | 0.0761 |
Median Liver PDFF (%) | 1453 | \(0.02 \pm 2.48\) | \(6.56 \pm 42.70\) | 0.5416 | 1449 | \(-0.15 \pm 3.11\) | \(4.27 \pm 42.98\) | 0.0141 |
Median Pancreas PDFF (%) | 1241 | \(-0.03 \pm 4.26\) | \(10.41 \pm 53.94\) | 0.3441 | 1254 | \(0.14 \pm 5.59\) | \(11.56 \pm 51.81\) | 0.0652 |
Median Paraspinal Muscle PDFF (%) | 1451 | \(0.06 \pm 1.82\) | \(6.50 \pm 35.06\) | 0.124 | 1446 | \(0.06 \pm 1.34\) | \(4.90 \pm 28.02\) | 0.0244 |
