Table 2 Results of GWAS meta-analysis for lean body mass (leading SNPs, top 10).

From: Unveiling genetic variants for age-related sarcopenia by conducting a genome-wide association study on Korean cohorts

Chr	SNP	Position	Allele	MAF	Independent study					Meta-analysis			Mapped genes
Chr	SNP	Position	Allele	MAF	Cohort	Effect	SE	MAF	P	Effect	SE	P (HetPVal)	Mapped genes
6	rs1187118	34169020	A/T	0.16^a, 0.11^b	VHSMC	0.488	0.208	0.16	\(1.89\times {10}^{-2}\)	0.720	0.117	\(1.09\times {10}^{-9}\) (0.1995)	GRM4, HMGA1 (intergenic)
6	rs1187118	34169020	A/T	0.16^a, 0.11^b	KARE	0.831	0.143	0.17	\(7.92\times {10}^{-9}\)	0.720	0.117	\(1.09\times {10}^{-9}\) (0.1995)	GRM4, HMGA1 (intergenic)
1	rs3768582	183553870	C/T	0.27^a, 0.35^b	VHSMC	0.637	0.177	0.23	\(3.42\times {10}^{-4}\)	0.554	0.100	\(4.09\times {10}^{-8}\) (0.5376)	NCF2 (intronic)
1	rs3768582	183553870	C/T	0.27^a, 0.35^b	KARE	0.516	0.122	0.27	\(2.63\times {10}^{-5}\)	0.554	0.100	\(4.09\times {10}^{-8}\) (0.5376)	NCF2 (intronic)
15	rs12441313	59015488	G/T	0.33^a, 0.35^b	VHSMC	0.473	0.161	0.32	\(3.35\times {10}^{-2}\)	0.475	0.094	\(4.74\times {10}^{-7}\) (0.8894)	ADAM10 (intronic)
15	rs12441313	59015488	G/T	0.33^a, 0.35^b	KARE	0.477	0.116	0.33	\(4.19\times {10}^{-5}\)	0.475	0.094	\(4.74\times {10}^{-7}\) (0.8894)	ADAM10 (intronic)
22	rs4822064	42279506	G/C	0.05^a, 0.06^b	VHSMC	0.663	0.350	0.05	\(5.91\times {10}^{-2}\)	0.974	0.199	\(1.05\times {10}^{-6}\) (0.3081)	SREBF2 (intronic)
22	rs4822064	42279506	G/C	0.05^a, 0.06^b	KARE	1.124	0.243	0.05	\(3.89\times {10}^{-6}\)	0.974	0.199	\(1.05\times {10}^{-6}\) (0.3081)	SREBF2 (intronic)
6	rs7453329	58721,863	C/T	0.41^a, 0.37^b	VHSMC	0.436	0.154	0.41	\(4.81\times {10}^{-3}\)	0.426	0.090	\(2.39\times {10}^{-6}\) (0.8283)	LINC00680-GUSBP4, NONE (intergenic)
6	rs7453329	58721,863	C/T	0.41^a, 0.37^b	KARE	0.421	0.111	0.41	\(1.51\times {10}^{-4}\)	0.426	0.090	\(2.39\times {10}^{-6}\) (0.8283)	LINC00680-GUSBP4, NONE (intergenic)
7	rs77502935	157290819	C/T	0.11^a, 0.10^b	VHSMC	0.430	0.241	0.12	\(7.50\times {10}^{-2}\)	0.651	0.138	\(2.56\times {10}^{-6}\) (0.3043)	LOC101927914 (ncRNA_intronic)
7	rs77502935	157290819	C/T	0.11^a, 0.10^b	KARE	0.762	0.170	0.11	\(7.71\times {10}^{-6}\)	0.651	0.138	\(2.56\times {10}^{-6}\) (0.3043)	LOC101927914 (ncRNA_intronic)
8	rs12156192	40763707	C/A	0.05^a, 0.04^b	VHSMC	− 0.663	0.300	0.07	\(2.75\times {10}^{-2}\)	− 0.805	0.174	\(3.83\times {10}^{-6 }\)(0.6457)	ZMAT4,SFRP1 (intergenic)
8	rs12156192	40763707	C/A	0.05^a, 0.04^b	KARE	− 0.879	0.215	0.06	\(4.37\times {10}^{-5}\)	− 0.805	0.174	\(3.83\times {10}^{-6 }\)(0.6457)	ZMAT4,SFRP1 (intergenic)
3	rs12497693	72400695	C/T	0.40^a, 0.34^b	VHSMC	0.624	0.155	0.39	\(6.15\times {10}^{-5}\)	0.414	0.089	\(4.33\times {10}^{-6}\) (0.0831)	LINC00870, RYBP (intergenic)
3	rs12497693	72400695	C/T	0.40^a, 0.34^b	KARE	0.311	0.109	0.40	\(4.52\times {10}^{-3}\)	0.414	0.089	\(4.33\times {10}^{-6}\) (0.0831)	LINC00870, RYBP (intergenic)
3	rs73872711	141110287	C/G	0.28^a, 0.27^b	VHSMC	0.401	0.166	0.30	\(1.61\times {10}^{-2}\)	0.437	0.096	\(6.11\times {10}^{-6}\) (0.8804)	ZBTB38 (intronic)
3	rs73872711	141110287	C/G	0.28^a, 0.27^b	KARE	0.457	0.119	0.29	\(1.26\times {10}^{-4}\)	0.437	0.096	\(6.11\times {10}^{-6}\) (0.8804)	ZBTB38 (intronic)
11	rs111357357	3640972	C/T	0.16^a, 0.13^b	VHSMC	0.421	0.208	0.16	\(4.30\times {10}^{-2}\)	0.533	0.119	\(8.29\times {10}^{-6}\) (0.5698)	LOC115995503, TRPC2 (intergenic)
11	rs111357357	3640972	C/T	0.16^a, 0.13^b	KARE	0.589	0.146	0.17	\(6.00\times {10}^{-5}\)	0.533	0.119	\(8.29\times {10}^{-6}\) (0.5698)	LOC115995503, TRPC2 (intergenic)

Chr, chromosome; SNP, single nucleotide polymorphism; MAF, minor allele frequency; SE, standard error; Mapped Genes from ANNOVAR; GWAS, genome-wide association study; VHSMC, Veterans Health Service Medical Center; KARE, Korean Association Resource.
^aKref, Korean reference data; ^bGnomAD Genome Aggregation Database (east Asian).

Back to article page

Table 2 Results of GWAS meta-analysis for lean body mass (leading SNPs, top 10).

Search

Quick links